The dried root of the plant picrorrhiza kurrooa Roleex Benth.
Length 6cm, 4 mm in diameter. Dark brown with white bands, flaky, ossified.
Picrorrhiza, Rhz. - HU HUANG LIAN - Asian brown seasoning
Dose: 9-16g/day
The bitter brown seasoning is an antibacterial and entkrampfendes resources in case of humid heat. In addition he stimulates the digestive glands and acts on brain mucus.
- Cardio protective
Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats
The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.
- Malaria
Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora
Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3μM. This compound accounted for ∼95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity.
- Colitis
Protective effect of apocynin in a mouse model of chemically-induced colitis
Treatment with apocynin and rutin ameliorated the course of colonic inflammation with results similar to those of the reference drug, as could be seen by reductions in the disease activity index scores and colon length.
- Neuroprotection
The neuroprotective effects of apocynin
In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies.
Several reports suggest that NADPH oxidase might also be implicated in other diseases such as Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), epilepsy, HIV-associated dementia, schizophrenia, alcohol-induced neurodegeneration, and sleep disorders.
4.1. Alzheimer
The neuroprotective effects of apocynin
There was a significant reduction in plaque load in the cortex and the hippocampus, and apocynin treatment also decreased the number of microglia in the cortex
4.2. Parkinsonism
– Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model
In conclusion, compensation for the loss of DA and its metabolite HVA by apocynin mitigates the PD progression and limits the parkinsonian signs and motor-function deterioration.
– The neuroprotective effects of apocynin
Most importantly, apocynin is also beneficial when used in vivo in different animal models of PD; preadministration of apocynin protects against paraquat-induced dopaminergic cell death in mice (80) and 6-OHDA-induced neurodegeneration in rats
4.3. Apoplex
The neuroprotective effects of apocynin
http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html
